Compile Data Set for Download or QSAR
Report error Found 363 Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2 [G101V]'
TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704933(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) | US20240376097...)
Affinity DataIC50: 0.0640nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705100(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0670nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705070(4-(6-((R)-4-((5,6- dimethoxypyridin-3-yl)methyl)-2...)
Affinity DataIC50: 0.0700nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704998(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(2-((R)-4...)
Affinity DataIC50: 0.0750nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705092(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.0770nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704932(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0790nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705030(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(6-((R)-4...)
Affinity DataIC50: 0.0840nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705093(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.0860nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705099(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R)-...)
Affinity DataIC50: 0.0890nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704925(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- (((R)-3-...)
Affinity DataIC50: 0.0930nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705091(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.0960nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705148(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.100nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705051((R)-2-((1H-pyrrolo[2,3-b]pyridin- 5-yl)oxy)-4-(6-(...)
Affinity DataIC50: 0.110nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705177(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.110nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705149(4-(6-((R)-4-((3,3-dimethy]-2,3- dihydro-[1,4]dioxi...)
Affinity DataIC50: 0.120nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704981(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-((...)
Affinity DataIC50: 0.130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705013(4-(2-((R)-4-(3,4-dimethoxybenzyl)-2-(2-isopropylph...)
Affinity DataIC50: 0.130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705025(4-(6-((R)-4-(3,4-dimethoxybenzyl)-2-(2-isopropylph...)
Affinity DataIC50: 0.130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705146(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704914(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705059(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705074(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705188(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704924(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704992(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R o...)
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705054(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-((...)
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705065(4-(6-((R)-4-(3,4-bis(methoxy-d3) benzyl)-2-(2-isop...)
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705165(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705064(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-((...)
Affinity DataIC50: 0.160nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705150(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.160nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705187(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.160nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704982(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705031(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705066(4-(2-((R)-4-(3,4-bis(methoxy-d3) benzyl)-2-(2-isop...)
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705069(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705076(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704929(synthesized from intermediate 19-1a in Method A”) ...)
Affinity DataIC50: 0.180nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705057((R)-2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)ox...)
Affinity DataIC50: 0.180nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705145(4-(6-((R)-4-((2,2-dimethyl-2,3- dihydro-[1,4]dioxi...)
Affinity DataIC50: 0.190nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704983(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704989(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-(3...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705062((R)-4-(2-(4-(3,4-dimethoxybenzyl)- 2-(2-isopropylp...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705090(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705136(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704920(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704961(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R o...)
Affinity DataIC50: 0.210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705039(2-((3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-...)
Affinity DataIC50: 0.220nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705063(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-(3...)
Affinity DataIC50: 0.230nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705184(2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-N...)
Affinity DataIC50: 0.240nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM567728(US11420968, Example F91b)
Affinity DataIC50: 0.25nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2-G101 protein with its ligand in an assay based on time-resolved fluorescence re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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