Compile Data Set for Download or QSAR
Report error Found 193 Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N]'
LigandPNGBDBM562369(US11401278, Example 42 | (−)-4-chloro-14-cyc...)
Affinity DataIC50: 1.20E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562386(US11401278, Example 57 | (+)-4-chloro-3,14-diethyl...)
Affinity DataIC50: 1.20E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM577692(US11478451, Example 096 | US11478451, Example 098 ...)
Affinity DataIC50: 1.20E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM562387(US11401278, Example 58 | (+)-4-chloro-3,14-diethyl...)
Affinity DataIC50: 1.30E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562382(US11401278, Example 53 | (rac)-4-chloro-14-cyclopr...)
Affinity DataIC50: 1.40E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562385(US11401278, Example 56 | (rac)-4-chloro-3,14-dieth...)
Affinity DataIC50: 1.40E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562391(US11401278, Example 62 | (+)-4-chloro-3-ethyl-7-{3...)
Affinity DataIC50: 1.40E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM572166(US11478451, Example 21 | (rac)-4-chloro-3-ethyl-2-...)
Affinity DataIC50: 1.40E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM572202(US11478451, Example 086 | (rac)-4-chloro-12,12-dif...)
Affinity DataIC50: 1.40E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM562350(US11401278, Example 23 | (rac)-13-Chloro-12-ethyl-...)
Affinity DataIC50: 1.50E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562384(US11401278, Example 55 | (+)-4-chloro-14-cycloprop...)
Affinity DataIC50: 1.60E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562390(US11401278, Example 61 | (+)-4-chloro-3-ethyl-7-{3...)
Affinity DataIC50: 1.60E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM572180(US11478451, Example 35 | (rac)-4-chloro-3-ethyl-7-...)
Affinity DataIC50: 1.60E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM577683(US11478451, Example 087 | US11478451, Example 089 ...)
Affinity DataIC50: 1.60E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM562388(US11401278, Example 59 | (rac)-4-chloro-3-ethyl-7-...)
Affinity DataIC50: 1.70E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562334(US11401278, Example 7 | (rac)-12-Ethyl-13-fluoro-1...)
Affinity DataIC50: 1.80E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562363(US11401278, Example 36 | (+)-4-chloro-3-ethyl-7-{3...)
Affinity DataIC50: 1.80E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM577689(US11478451, Example 093)
Affinity DataIC50: 1.80E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM577698(US11478451, Example 103 | (rac)-3-chloro-4-ethyl-1...)
Affinity DataIC50: 1.80E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM577706(US11478451, Example 111 | (+)-4′-chloro-3...)
Affinity DataIC50: 1.80E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM562368(US11401278, Example 41 | (rac)-4-chloro-14-cyclopr...)
Affinity DataIC50: 1.90E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562392(US11401278, Example 63 | (+)-4-chloro-3-ethyl-7-{3...)
Affinity DataIC50: 1.90E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM572157(US11478451, Example 10 | 4-chloro-3-ethyl-1-[2-(mo...)
Affinity DataIC50: 1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM572192(US11478451, Example 47 | (rac)-4-chloro-3-ethyl-14...)
Affinity DataIC50: 1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM577663(US11478451, Example 67 | (rac)-4-chloro-11,11,12,1...)
Affinity DataIC50: 1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM572210(US11478451, Example 081 | US11447504, Example 64 |...)
Affinity DataIC50: 1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM577717(US11478451, Example 123 | (rac)-4-chloro-3-ethyl-7...)
Affinity DataIC50: 1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
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LigandPNGBDBM562256(US11401278, Example 1 | US11401278, Example 2 | US...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562256(US11401278, Example 1 | US11401278, Example 2 | US...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562256(US11401278, Example 1 | US11401278, Example 2 | US...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562331(US11401278, Example 4 | US11401278, Example 5 | (r...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562331(US11401278, Example 4 | US11401278, Example 5 | (r...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562331(US11401278, Example 4 | US11401278, Example 5 | (r...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562335(US11401278, Example 8 | (+)-3-Ethyl-4-fluoro-7-{3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562336(US11401278, Example 9 | (−)-3-Ethyl-4-fluoro...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562338(US11401278, Example 11 | (+)-2,3,14-Trimethyl-7-[3...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562339(US11401278, Example 12 | (−)-2,3,14-Trimethy...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562340(US11401278, Example 13 | (rac)-12-Ethyl-11-methyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562341(US11401278, Example 14 | (rac)-12-Ethyl-11-methyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562342(US11401278, Example 15 | (rac)-12-Ethyl-11-methyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562343(US11401278, Example 16 | (rac)-12-Ethyl-11-methyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562344(US11401278, Example 17 | (rac)-12-Ethyl-11-methyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562345(US11401278, Example 18 | 12-Ethyl-8,9,11-trimethyl...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562346(US11401278, Example 19 | (rac)-13-Chloro-12-ethyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562347(US11401278, Example 20 | (rac)-13-Chloro-12-ethyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562348(US11401278, Example 21 | (rac)-13-Chloro-1-(3-((2,...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562349(US11401278, Example 22 | (rac)-13-Chloro-1-(3-(4-c...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562351(US11401278, Example 24 | (rac)-13-Chloro-12-ethyl-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562352(US11401278, Example 25 | (rac)-13-Fluoro-1-(3-((6-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562353(US11401278, Example 26 | (rac)-13-Fluoro-8,11,12-t...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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