Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein [672-711]'
TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250505(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 5.40nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250501(US9464103, (6'S,6aR,7s,10aS)-10a-(4-chlorobenz...)
Affinity DataIC50: 9.5nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129277(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 10.1nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129269(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 13.9nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129272(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 23.3nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129278(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 26.4nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129271(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 57.7nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129276(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 66.6nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250504(US9464103, (6'S,6aR,7s,10aS)-1,4-difluoro-6'-methy...)
Affinity DataIC50: 79nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129270(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 228nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250503(US9464103, (6'R,6aR,7r,10aS)-1,4-difluoro-6'-methy...)
Affinity DataIC50: 397nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250502(US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenz...)
Affinity DataIC50: 421nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent