Compile Data Set for Download or QSAR
Report error Found 14156 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1'
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493155(CHEMBL2419148)
Affinity DataKi:  0.000590nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493144(CHEMBL2419144)
Affinity DataKi:  0.000630nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493151(CHEMBL2419139)
Affinity DataKi:  0.000740nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM82013(NSC_92411 | 8-(2-Amino-4-chlorophenyl)-1,3-dipropy...)
Affinity DataKi:  0.0220nMAssay Description:Inhibitory activity against adenosine A1 receptor in bovine brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50149598(CHEMBL3770679)
Affinity DataIC50: 0.0295nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50207816(N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315544(8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazo...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50006730(R-N6-(2-phenylisopropyl) adenosine | S-PIA | (R)-2...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191826(US9187428, 54)
Affinity DataEC50:  0.0400nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191818(US9187428, 46)
Affinity DataEC50:  0.0400nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM82013(NSC_92411 | 8-(2-Amino-4-chlorophenyl)-1,3-dipropy...)
Affinity DataIC50: 0.0500nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50020986(CHEMBL11002 | N-(2-Dimethylamino-ethyl)-4-(2,6-dio...)
Affinity DataIC50: 0.0500nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50594655(CHEMBL5177144)
Affinity DataKi:  0.0510nMAssay Description:Binding affinity to human adenosine A1A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191778(US9187428, 6)
Affinity DataEC50:  0.0600nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataKi:  0.0628nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataIC50: 0.0670nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50021010(CHEMBL545362 | N-(4-Dimethylamino-butyl)-4-(2,6-di...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.0709nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50: 0.0756nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50594654(CHEMBL5171044)
Affinity DataKi:  0.0760nMAssay Description:Binding affinity to human adenosine A1A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50: 0.0763nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50021008(CHEMBL11036 | N-(3-Dimethylamino-propyl)-4-(2,6-di...)
Affinity DataIC50: 0.0800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191785(US9187428, 13)
Affinity DataEC50:  0.0800nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50207816(N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataIC50: 0.0840nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataKi:  0.0867nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataIC50: 0.0929nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50062858(8-Cyclopentyl-3-(2-fluoro-propyl)-1-propyl-3,7-dih...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]CPX from Adenosine A1 receptor of bovine brain cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315538(8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1...)
Affinity DataKi:  0.0960nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataIC50: 0.0981nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191850(US9187428, 78)
Affinity DataEC50:  0.100nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50161342(2-amino-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one |...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DPCPX from A1 adenosine receptor (unknown origin) expressed in CHO cell membrane incubated for 60 mins at room temperature by NXT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493148(CHEMBL2419137)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50588454(CHEMBL5174052)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM191779(US9187428, 7)
Affinity DataEC50:  0.100nMpH: 7.4 T: 2°CAssay Description:The stock cultures are grown, at 37° C. and under 5% CO2, in DMEM/F12 medium containing 10% FCS (fetal calf serum) and in each case split 1:10 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetAdenosine receptor A1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50008408(CHEMBL133982 | 3-(4-Amino-3-iodo-phenyl)-N-(2-{2-[...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for adenosine A1 receptor using [3H]- CHA or [3H]- PIA in bovine brain cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50: 0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50003646(CHEMBL3235279)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at adenosine A1 receptor (unknown origin) expressed in CHO cells assessed as increase in intracellular cAMP level by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50375517(CHEMBL411245)
Affinity DataIC50: 0.120nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50588462(CHEMBL5195714)
Affinity DataEC50:  0.123nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550813(CHEMBL1316674)
Affinity DataKi:  0.124nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50494549(CHEMBL3093327)
Affinity DataKi:  0.124nMAssay Description:Binding affinity to rat adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50588460(CHEMBL5187330)
Affinity DataEC50:  0.132nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50517299(CHEMBL4533718)
Affinity DataIC50: 0.140nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP production after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Mouse)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50517301(CHEMBL1877326)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50588447(CHEMBL5172389)
Affinity DataEC50:  0.141nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
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