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Report error Found 26 Enz. Inhib. hit(s) with Target = 'Adenosine 5'-monophosphoramidase HINT1'
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426059(US10513520, Compound 6)
Affinity DataKd:  920nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  5.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  318nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50535047(CHEMBL4468179)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50535046(CHEMBL4549820)
Affinity DataKd:  920nMAssay Description:Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50535045(CHEMBL4455776)
Affinity DataKd:  810nMAssay Description:Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50119454(CHEMBL3140272)
Affinity DataKd:  320nMAssay Description:Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50535044(CHEMBL4471567)
Affinity DataKd:  230nMAssay Description:Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360481(CHEMBL1934757)
Affinity DataKd:  3.65E+3nMAssay Description:Binding affinity to recombinant human HINT1 by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426061(guanosine monophosphate | US10513520, Compound GMP)
Affinity DataKd:  6.70E+4nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426060(US10513520, Compound 7)
Affinity DataKd:  230nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426058(US10513520, Compound 5)
Affinity DataKd:  2.90E+3nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426057(US10513520, Compound 4)
Affinity DataKd:  810nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM426056(US10513520, Compound 3)
Affinity DataKd:  3.65E+3nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetAdenosine 5'-monophosphoramidase HINT1(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50326433(((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to mouse HINT1 by NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22579(Aminoimidazole-4-carboxamide ribonucleotide | CHEM...)
Affinity DataKd:  1.20E+6nMAssay Description:Binding affinity to mouse HINT1 by HSQC spectra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22579(Aminoimidazole-4-carboxamide ribonucleotide | CHEM...)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to mouse HINT1 by fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50326433(((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataKd:  6.70E+4nMAssay Description:Binding affinity to mouse HINT1 by fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50119454(CHEMBL3140272)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells using TrpAMP as substrate measured for 2 to 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360481(CHEMBL1934757)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells using TrpAMP as substrate measured for 2 to 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360481(CHEMBL1934757)
Affinity DataKi:  3.40E+4nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360480(CHEMBL1934756)
Affinity DataKi:  1.03E+5nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360478(CHEMBL1934754)
Affinity DataKi:  1.39E+5nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360476(CHEMBL1934752)
Affinity DataKi:  4.00E+5nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360477(CHEMBL1934753)
Affinity DataKi:  4.57E+5nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50360479(CHEMBL1934755)
Affinity DataKi:  7.15E+5nMAssay Description:Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed