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Report error Found 15 Enz. Inhib. hit(s) with Target = 'Acetyl-CoA acetyltransferase, mitochondrial'
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637887(Eldacimibe | Eldacimiba | ACA-147 | ACA147 | WAY-A...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 44nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50599921(CHEMBL5203276)
Affinity DataIC50: 45nMAssay Description:Inhibition of human ACAT1 in HepG2 cells assessed as inhibition of triglyceride synthesis incubated for 1 hrs followed by 13C-addition of 13C-oleic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM182848(US9149492, Eflucimibe (F12511))
Affinity DataIC50: 59nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50047557(1-Butyl-3-{2-[3-(5-ethyl-4-phenyl-imidazol-1-yl)-p...)
Affinity DataIC50: 97nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 112nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637888(CHEMBL5542126)
Affinity DataIC50: 113nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50: 183nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 239nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  533nMAssay Description:Binding affinity to human ACAT1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239991(CB-313 | Lysodren | Mitotane | Opddd | o,p''-DDD)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50599923(CHEMBL5204128)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human ACAT1 in HepG2 cells assessed as inhibition of triglyceride synthesis incubated for 1 hrs followed by 13C-addition of 13C-oleic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM289003(US10093650, Example 16 | US10093650, Example 14 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human ACAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetAcetyl-CoA acetyltransferase, mitochondrial(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346601(Oleanolic acid (OA)(Compound 1) | NSC-114945 | OLE...)
Affinity DataIC50: 7.79E+4nMAssay Description:Inhibition of rat liver microsomal ACATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed