Report error Found 6332 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 6'
Affinity DataKi: 0.0400nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0500nM ΔG°: -58.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0660nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0740nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0794nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0830nM ΔG°: -57.5kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.0850nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0850nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0880nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0920nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nM ΔG°: -57.1kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO-K1 cell membranes incubated for 1 hr by scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nM ΔG°: -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nM ΔG°: -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nM ΔG°: -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.112nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nM ΔG°: -56.6kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nM ΔG°: -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nM ΔG°: -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nM ΔG°: -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nM ΔG°: -56.1kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nM ΔG°: -55.9kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
