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Report error Found 29 Enz. Inhib. hit(s) with Target = '2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase'
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443774(CHEMBL3094106)
Affinity DataKd:  9.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31916(Tryptophanhydroxamate, 13)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to Escherichia coli IspF at pH 7.4 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31916(Tryptophanhydroxamate, 13)
Affinity DataKd:  2.40E+4nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 8 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31916(Tryptophanhydroxamate, 13)
Affinity DataKd:  8.48E+5nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 6 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50043799((2R)-2-amino-3-(1H-indol-3-yl)propanoic acid | (R)...)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50566954(CHEMBL4874588)
Affinity DataKd:  6.40E+4nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31916(Tryptophanhydroxamate, 13)
Affinity DataKd:  3.60E+4nMAssay Description:Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443775(CHEMBL3094105)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31907(5-oxopentanoic acid, 4)
Affinity DatapH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443773(CHEMBL1230528)
Affinity DataKd:  1.35E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50194153(5'-CDP | Cytidine 5'-pyrophosphate | CDP | Cytidin...)
Affinity DataKd:  7.50E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443771(CHEMBL3094103)
Affinity DataKd:  1.48E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31909(Cytidine 2,3-cyclic phosphate, 6)
Affinity DataKd:  2.05E+7nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31910(Cyclic CMP, 7)
Affinity DataKd:  9.00E+5nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31911(2-[(2,6-diaminopyrimidin-4-yl)sulfanyl]acetamide, ...)
Affinity DatapH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31912(4-(5-amino-1,3,4-oxadiazol-2-yl)-1,2,5-oxadiazol-3...)
Affinity DatapH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31913(cytidylic acid | 1-beta-D-arabinofuranosylcytosine...)
Affinity DataKd:  1.89E+7nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31914(FLUC | 4-amino-1-[(2R,3R,4S,5R)-3, 4-dihydroxy-5-(...)
Affinity DataKd:  2.02E+6nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31915(HPMPC | Vistide | CDV | Cidofovir | US10071110, Co...)
Affinity DataKd:  4.00E+7nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM31916(Tryptophanhydroxamate, 13)
Affinity DataKd:  1.92E+3nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443770(CHEMBL3094104)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443772(CHEMBL1230597)
Affinity DataKd:  1.80E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50488587(CHEMBL2289486)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Arabidopsis thaliana IspF expressed in Escherichia coli XL1-Blue after 30 min by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50502707(CHEMBL4458954)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of Salmonella typhimurium IspF by malachite green dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50502708(CHEMBL3222163)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of Salmonella typhimurium IspF by malachite green dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50496771(CHEMBL3220831)
Affinity DataIC50: 3.43E+5nMAssay Description:Inhibition of Escherichia coli IspF-MEP complex by HPLC based cAMP formation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50194153(5'-CDP | Cytidine 5'-pyrophosphate | CDP | Cytidin...)
Affinity DataIC50: 7.68E+5nMAssay Description:Inhibition of Escherichia coli IspF by HPLC based cAMP formation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50496771(CHEMBL3220831)
Affinity DataIC50: 7.97E+5nMAssay Description:Inhibition of Escherichia coli IspF by HPLC based cAMP formation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed