BDBM9920 (S)Fadrozole::4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile::4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl]benzonitrile::CHEMBL31215

SMILES c1cc(ccc1C#N)[C@@H]2CCCc3n2cnc3

InChI Key InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N

Data  7 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 9920   

TargetAromatase(Human)
University of Bologna

LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 171nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticosterone for 3 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human aldosterone synthase expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticost...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human CYP11B1 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 171nMAssay Description:Inhibition of human CYP11B2 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM9920(CHEMBL31215 | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]py...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human CYP11B2 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)