BDBM81497 4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrrolo[1,2-a]quinoxaline::CAS_109028-10-6::CGS 12066B::CHEMBL27403::NSC_123945

SMILES CN1CCN(CC1)c1nc2cc(ccc2n2cccc12)C(F)(F)F

InChI Key InChIKey=LXFHSCDLMBZYKY-UHFFFAOYSA-N

Data  27 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 81497   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 1.00E+4nMAssay Description:inhibitory activity against 5-hydroxytryptamine 1C receptor of pig choroid plexus using [3H]mesulergine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 339nMAssay Description:Binding affinity for 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Bovine)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 1.86E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Pig)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 123nMAssay Description:Binding affinity for 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 9.77E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 339nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 46.8nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 1.32E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 1.32E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1B receptor of rat substantia nigraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 46.8nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 9.77E+4nMAssay Description:Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Pig)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 123nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Bovine)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 1.86E+4nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 6.80E+3nMAssay Description:Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 2 receptor of rat anterior cortex using [3H]ketanserin as the radiolig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 35nMAssay Description:Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.08nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.69nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  4.89nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  7.41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  9.5nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2011
Entry Details
PubMed
Target5-hydroxytryptamine 1D receptor(Bovine)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  148nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  580nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
National Institute of Neurological Disorders and Stroke

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  738nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  871nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  1.53E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  1.74E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  2.51E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  3.13E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  4.27E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  6.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed