BDBM77970 3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-1-propanamine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-dimethyl-amine;hydrochloride::CHLORIMIPRAMINE::CLOMIPRAMINE::CLOMIPRAMINE HYDROCHLORIDE::CLOMIPRIMINE::MLS000028511::SMR000058295::US20240358711, Compound Clomipramine::cid_68539::med.21724, Compound Clomipramine

SMILES CN(C)CCCN1c2ccccc2CCc3c1cc(cc3)Cl

InChI Key InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N

Data  59 KI  30 IC50  1 Kd  3 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 77970   

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 20nMAssay Description:Inhibition of uptake of 5-HT in rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 0.0400nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 0.200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of uptake of dopamine (DA) rat brain striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 700nMAssay Description:Inhibition of uptake of noradrenaline in rat brain hypothalamusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 70nMAssay Description:In vivo inhibition of uptake of 5-HT in human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
Canisius College

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei brucei strain S427 trypanothione reductase assessed as reduction of trypanothione disulphide by 412 nm a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 900nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 900nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 90nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataEC50:  1.24E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21 (DE3) pre-incubated for 30 mins using TS2 substrate in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Mouse)
Immunyx Pharma

US Patent
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 3.50E+3nMAssay Description:A high-throughput screen was performed to find molecules that inhibit ROS production by neutrophils. Extracted human neutrophils were purified and ke...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Immunyx Pharma

US Patent
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:A high-throughput screen was performed to find molecules that inhibit ROS production by neutrophils. Extracted human neutrophils were purified and ke...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR measured after 15 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sogang University

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 65nMAssay Description:Displacement of [3H]Nisoxetine from human recombinant NET over-expressed in dog MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sogang University

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 2.78E+3nMAssay Description:Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataEC50:  1.32E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataEC50:  9.33E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetMitochondrial import inner membrane translocase subunit TIM10(Baker's yeast)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 3.78E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKd:  1.18E+5nMAssay Description:Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 3.74E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  5.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  9.42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  14.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKi:  15.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
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