BDBM765332 N-(3-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-6-((S)-3-hydroxypyrrolidin-1-yl)nicotinamide::US12391687, Example 3

SMILES O=C(Nc1cnc2[nH]nc(N3CCC[C@@H]3c3cc(F)ccc3F)c2c1)c1ccc(N2CC[C@H](O)C2)nc1

InChI Key InChIKey=VJCFLMVIATXBSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 765332   

TargetNT-3 growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 765332BDBM765332(N-(3-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 50nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 765332BDBM765332(N-(3-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 50nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 765332BDBM765332(N-(3-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 100nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent