BDBM7496 14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::4-Azakenpaullone

SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1

InChI Key InChIKey=YZVVOFLCHCBTMZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7496   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Technische Universitat Braunschweig

LigandPNGBDBM7496(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 8.40E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Technische Universitat Braunschweig

LigandPNGBDBM7496(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 1.20E+4nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Technische Universitat Braunschweig

LigandPNGBDBM7496(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 6.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7496(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7496(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed