BDBM73521 10-(4-fluorobenzyl)-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole hydrochloride::10-(4-fluorobenzyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole;hydrochloride::10-[(4-fluorophenyl)methyl]-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole;hydrochloride::MLS000681001::SMR000269262::cid_2899152

SMILES c1ccc2c(c1)N3CCCN=C3N2Cc4ccc(cc4)F

InChI Key InChIKey=LXOFDRFYSDHQTI-UHFFFAOYSA-N

Data  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 73521   

TargetProtein LANA1(HHV-8)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM73521(10-(4-fluorobenzyl)-2,3,4,10-tetrahydropyrimido[1,...)
Affinity DataEC50: >7.50E+4nMAssay Description:Primary Collaborators: Kenneth Kaye,Brigham & Womens,Boston MA,kkaye@rics.bwh.harvard.edu,617-525-4256 Chantal Beauchemin,Brigham & Womens,Boston MA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM73521(10-(4-fluorobenzyl)-2,3,4,10-tetrahydropyrimido[1,...)
Affinity DataEC50:  6.30E+4nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM73521(10-(4-fluorobenzyl)-2,3,4,10-tetrahydropyrimido[1,...)
Affinity DataEC50:  6.30E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)