BDBM660659 N-(2-ethylpyrimidin-5-yl)-6- ((1- fluorocyclopropyl)methoxy)iso- quinolin-1-amine::US20240101531, Example 44

SMILES CCc1ncc(Nc2nccc3cc(OCC4(F)CC4)ccc23)cn1

InChI Key InChIKey=PBIHSGNQJUKHNH-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 660659   

TargetVoltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 660659BDBM660659(N-(2-ethylpyrimidin-5-yl)-6- ((1- fluorocyclopropy...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent