BDBM657340 6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazolin-4-amine::US20240083857, Example Reference

SMILES C[C@H](c1cccc2c1cccc2)Nc3c4cc(c(cc4ncn3)OC)OC

InChI Key InChIKey=YREPTYNUQVYXCF-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 657340   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 304nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 263nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 693nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 553nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human His-tagged SOS1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 580nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed