BDBM65501 8-pCP-cGMP::Cyclic GMP analogs::cGMP

SMILES c1cc(ccc1Sc2nc3c(n2[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O)NC(=NC3=O)N)Cl

InChI Key InChIKey=ZDJHIEHUVPCEDK-UHFFFAOYSA-N

Data  16 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 65501   

TargetIsoform Beta of cGMP-dependent protein kinase 1 [1-351](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  163nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  206nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  4.20nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  7.70nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  370nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  249nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2(Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  257nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2(Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  22nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  96nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  5nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418,G232E](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  184nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418,G232E](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  116nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418,G356E](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  50nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsoform Beta of cGMP-dependent protein kinase 1 [1-351](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  212nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 2 [41-418,G356E](Human)
Baylor College of Medicine

LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50: <1nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM65501(Cyclic GMP analogs | 8-pCP-cGMP | cGMP)
Affinity DataEC50:  328nMpH: 7.0Assay Description:Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)