BDBM64562 US9428505, Compound 7

SMILES Cc1cc(cc(c1CCS(=O)(=O)N2CCC3(CC2)C(=O)NC(=N3)c4ccc(cc4)OC(F)(F)F)C)N5C(=O)NC(=O)C5(C)C

InChI Key InChIKey=LDZJFVOUPUFOHX-UHFFFAOYSA-N

Data  3 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 64562   

TargetParathyroid hormone [32-65](Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM64562(US9428505, Compound 7)
Affinity DataEC50:  4.10E+3nMpH: 7.4Assay Description:HKRK-B7 or LLC-PK1 cells were seeded into a 96-well plate at 1×105 cells/well and incubated overnight. On the following day, 50 μl of cAMP assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2017
Entry Details
Go to US Patent

TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Rat)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM64562(US9428505, Compound 7)
Affinity DataEC50:  2.40E+3nMpH: 7.4Assay Description:Instead of HKRK-B7 cells, LLC-PK46_RATO_PTH1R cells overexpressing rat PTH1R, which were established at Chugai Pharmaceutical, were used to take meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM64562(US9428505, Compound 7)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)