BDBM639154 US20230391736, Example S-217622::US20250025459, Compound I-005::US20250127788, Compound I-005::US20250188102, Compound CVL201

SMILES Cn1cc2cc(c(cc2n1)Cl)NC3=NC(=O)N(C(=O)N3Cc4cc(c(cc4F)F)F)Cc5ncn(n5)C

InChI Key InChIKey=QMPBBNUOBOFBFS-UHFFFAOYSA-N

Data  13 IC50

PDB links: 22 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 639154   

TargetReplicase polyprotein 1a(2019-nCoV)
Shaanxi Panlong Pharmaceutical Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 33nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined by fluorescence resonance energy transfer technique. A suitable amo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetReplicase polyprotein 1a(2019-nCoV)
Shaanxi Panlong Pharmaceutical Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 10nMAssay Description:In this test, an assay buffer consisting of 20 mM Tris-HCl, 100 mM sodium chloride, 1 mM EDTA, 10 mM DTT, and 0.01% BSA is used. For compounds with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
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TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details
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TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 18.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1ab [E3429V](2019-nCoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 1.47E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1a [P3395H](2019-nCoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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PDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(SARS-CoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(MERS-CoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 4.96E+6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(HCoV-229E)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 5.63E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1ab(HCoV-OC43)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 134nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1ab(HCoV-HKU1)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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TargetReplicase polyprotein 1ab(HCoV-NL63)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 2.78E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
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PDB3D3D Structure (crystal)