BDBM60517 US9085555, 124

SMILES c1ccc2c(c1)c(cn2C(=O)N)NC(=O)N3CCC[C@H]3C(=O)Nc4cccc(c4)OC(F)(F)F

InChI Key InChIKey=GPEWMCZCFCZAEI-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 60517   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in expressed in Escherichia coli(Rosetta) using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-7(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human kallikrein 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human coagulation factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 8.80E+3nMAssay Description:Antagonist activity at adenosine 3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM60517(US9085555, 124)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)