BDBM603009 N-(3-(5-Chloro-2-methoxyphenyl)-1- methyl-1H-pyrazol-4-yl)-H- pyrazolo[4,3-c]pyridine-7- carboxamide::US11649241, Example 2

SMILES COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2cn[nH]c12

InChI Key InChIKey=NBFASNUBTMTAFQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 603009   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM603009(N-(3-(5-Chloro-2-methoxyphenyl)-1- methyl-1H-pyraz...)
Affinity DataKi:  0.350nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM603009(N-(3-(5-Chloro-2-methoxyphenyl)-1- methyl-1H-pyraz...)
Affinity DataKi:  1.35nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent