BDBM601877 US11643396, Example MA4-022-2

SMILES Cc1cnc(nc1Nc2ccc(c(c2)NS(=O)(=O)C(C)(C)C)Cl)Nc3ccc(c(c3)F)N4CCN(CC4)C

InChI Key InChIKey=QHSBHADJYBAJTJ-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 601877   

TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 4.80nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 4.80nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 11.2nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 19nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 3.36nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 10.7nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601877(US11643396, Example MA4-022-2)
Affinity DataIC50: 66nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent