BDBM601857 US11643396, Example SG3-014

SMILES Cc1cnc(nc1Nc2ccc(c(c2)NS(=O)(=O)C(C)(C)C)Cl)Nc3ccc(cc3)N4CCN(CC4)C

InChI Key InChIKey=OKUXIUAKYDKHDY-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 601857   

TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 10nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 10nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 81.4nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 16.5nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 25nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 27.8nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 11.2nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 9.71nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM601857(US11643396, Example SG3-014)
Affinity DataIC50: 142nMAssay Description:The HotSpot Kinase Assay is used at our US facility for compound screening on protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent