BDBM601197 N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-1-(5-oxo-4,5-dihydro-::US11634395, Example 222A::US11634395, Example 222B::US11634395, Example 226A::US11634395, Example 226B

SMILES Cc1c(Br)ccc(F)c1[C@@H](C)[C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCCC2(C)O)c1n[nH]c(=O)o1

InChI Key InChIKey=XELMJOZTBDQHDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 601197   

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandChemical structure of BindingDB Monomer ID 601197BDBM601197(US11634395, Example 222B | US11634395, Example 226...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandChemical structure of BindingDB Monomer ID 601197BDBM601197(US11634395, Example 222B | US11634395, Example 226...)
Affinity DataIC50: 60nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandChemical structure of BindingDB Monomer ID 601197BDBM601197(US11634395, Example 222B | US11634395, Example 226...)
Affinity DataIC50: 70nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandChemical structure of BindingDB Monomer ID 601197BDBM601197(US11634395, Example 222B | US11634395, Example 226...)
Affinity DataIC50: 80nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent