BDBM589316 US11555012, Compound I-65::US20250011272, Example DN1-091143

SMILES COC(=O)c1cc(Cl)c(O)c(c1)S(=O)(=O)Nc1cc(c(F)cc1F)-c1ccccc1

InChI Key InChIKey=YSTSHUWHIDBZAK-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 589316   

TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataIC50: 50nMAssay Description:Materials and Instruments Used in the ADP-Glo AssayVendor Cat No.Materials ACL Sino Biological 11769-H07BCoANa2 Sigma C3144Potassium Citrate Sigma 89...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
Go to US Patent

TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ACLY (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to ACLY (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant ACLY by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataIC50: 2.10nMAssay Description:Experimental method: ADP Glo luminescence method was used for determination. It reflects the activity of ACLY enzyme by quantitatively detecting the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetATP-citrate synthase(Human)
Nimbus Artemis

US Patent
LigandPNGBDBM589316(US11555012, Compound I-65 | US20250011272, Example...)
Affinity DataKi:  7.00E+6nMAssay Description:Binding affinity to ACLY (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed