BDBM552521 WO2022098809, Example 4-8

SMILES CN1CCc2cc(c(cc2C1)Nc3ncc(c(n3)Nc4c(cccc4F)C(F)(F)F)C(=O)N)OC

InChI Key InChIKey=RZLXOEIALAVGKH-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 552521   

LigandPNGBDBM552521(WO2022098809, Example 4-8)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM552521(WO2022098809, Example 4-8)
Affinity DataIC50: 453nMAssay Description:Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM552521(WO2022098809, Example 4-8)
Affinity DataIC50: 0.25nMAssay Description: Compounds are serially diluted (3-fold in 100% DMSO) across a 384-well polypropylene source plated from column 3 to column 12 and column 13 to colum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022098809
PDB3D3D Structure (crystal)