BDBM548235 (R)-7-isopropyl-2-((R)-3-methylmorpholino)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one::WO2022093820, Compound 1

SMILES C[C@@H]1COCCN1c2cc3n(n2)[C@@H](CNC3=O)C(C)C

InChI Key InChIKey=CYPSSQPWVAKPSS-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 548235   

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Genentech

WIPO

LigandBDBM548235((R)-7-isopropyl-2-((R)-3-methylmorpholino)-6,7-dih...)Copy SMILESCopy InChI

Affinity DataIC50: 78nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 µl per well, an enzyme ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2022
Entry Details
Copy Entry DOIWIPO WO2022093820
PDB3D Structure (crystal)
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Genentech

WIPO

LigandBDBM548235((R)-7-isopropyl-2-((R)-3-methylmorpholino)-6,7-dih...)Copy SMILESCopy InChI

Affinity DataIC50: 78nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/22/2023
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL