BDBM521202 3-(4-ethoxy-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2H- thiochromen-7- ol::US11149031, Example 26

SMILES CCOc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3SC2)c(F)c1

InChI Key InChIKey=WFVKBCDKHSMRJR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521202   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521202BDBM521202(3-(4-ethoxy-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 3nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521202BDBM521202(3-(4-ethoxy-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 39nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521202BDBM521202(3-(4-ethoxy-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 67nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent