BDBM50612195 CHEMBL5288931

SMILES CN1CCC(CC1)n1cc(Nc2nc(OC3(C)CC3)c3nc(c(F)cc3n2)-c2cnc(C)nc2)cn1

InChI Key InChIKey=SZURKEABSBIIMJ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50612195   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 110nMAssay Description:Inhibition of IRAK4 (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of IRAK1 (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of BTK (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of 600 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 53nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of 75 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 270nMAssay Description:Inhibition of TRKA (unknown origin) in presence of 400 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 760nMAssay Description:Inhibition of TRKB (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: 270nMAssay Description:Inhibition of TRKC (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed