BDBM50610152 CHEMBL5268912

SMILES Cc1cc(ccc1NC(=O)c2cc(c(cc2Cl)F)C(=O)NCc3ccc(cc3COCCOC)F)C(F)(F)F

InChI Key InChIKey=PVTRYMNBUCBYEB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50610152   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50610152(CHEMBL5268912)
Affinity DataEC50:  31nMAssay Description:Inverse agonist activity at GST tagged human PPARgamma LBD (231 to 505 residues) expressed in Escherichia coli BL21(DE3) assessed as recruitment of f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50610152(CHEMBL5268912)
Affinity DataIC50: 7.40nMAssay Description:Inverse agonist activity at human PPARgamma in human RT112/84 transfected with NLuc-fused FABP4 assessed as reduction in PPARgamma transactivation in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)