BDBM50605906 CHEMBL5172767

SMILES COc1ccc(cn1)-c1ccc2[nH]c(=O)c3nnn(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1

InChI Key InChIKey=RGHLRMNPUGUZEY-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50605906   

TargetSerine/threonine-protein kinase RIO2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605906(CHEMBL5172767)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system assessed as dissociation cons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605906(CHEMBL5172767)
Affinity DataIC50: 139nMAssay Description:Inhibition of N-terminal hexahistidine-SUMO-tagged human full length RIOK2 (residues 1 to 321) expressed in Escherichia coli BL21 (DE3) incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605906(CHEMBL5172767)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to RIOK2 (unknown origin) assessed as dissociation constant by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed