BDBM50604023 CHEMBL5192977

SMILES OCc1cc(ncc1-c1ccc(cc1)C1(COC1)C(=O)Nc1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=KTZHBUHZJXHRMG-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50604023   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFN gamma-stimulated human HeLa cells measured after 48 hrs by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataIC50: 2.28E+7nMAssay Description:Inhibition of MK-499 binding to hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataKd:  0.158nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed