BDBM50602103 CHEMBL5180914

SMILES COc1cc2c3cc1OCCOCCOCCOc4cc(c(cc4Nc3ncn2)Cl)F

InChI Key InChIKey=HPMIGMHXZFMMPF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50602103   

TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602103(CHEMBL5180914)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602103(CHEMBL5180914)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of EGFR (unknown origin) Del19 mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602103(CHEMBL5180914)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of EGFR (unknown origin) L858R mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602103(CHEMBL5180914)
Affinity DataIC50: 361nMAssay Description:Inhibition of EGFR (unknown origin) L858R/T790M mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)