BDBM50602085 CHEMBL5206697

SMILES COc1cc2c(cc1O)c(ncn2)Nc3cc(c(cc3O)F)Cl

InChI Key InChIKey=FFOVHTBAXFHJMK-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50602085   

TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602085(CHEMBL5206697)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602085(CHEMBL5206697)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR (unknown origin) Del19 mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602085(CHEMBL5206697)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR (unknown origin) L858R mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50602085(CHEMBL5206697)
Affinity DataIC50: 609nMAssay Description:Inhibition of EGFR (unknown origin) L858R/T790M mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)