BDBM50601084 CHEMBL5192659::US11702418, Example 12-10

SMILES Cc1c(cccc1[C@@H](C)Nc2c3cc(ncc3c(nn2)C)N4CCOCC4)C#N

InChI Key InChIKey=ILPWEAHQRAWJIU-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50601084   

TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataIC50: 46nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR in presence of ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataKi:  1.78nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)