BDBM50600305 CHEMBL5193672

SMILES COc1ccc(cc1)C2(CCCC2)C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc4cccc5c4cn[nH]5

InChI Key InChIKey=VWZAAFMUYDNGED-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50600305   

TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 150nMAssay Description:Inhibition of N-terminal His tagged human EP300 (1159-1666 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H4 (1 to 25)-GSGSK p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 450nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular histone H3 acetylation at lysine 27 residue incubated for 3 hrs by chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 40nMAssay Description:Inhibition of CBP (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT5(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GST tagged human TIP60 expressed in Sf9 cells using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT7(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MYST2 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT6B(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MYST4 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GST tagged human PCAF (431 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed