BDBM50598851 CHEMBL5199076::US20240207300, Compound 292

SMILES Cc1ccc(c(c1n2c(c(c3c2nc(c(c3)C)C)C(=O)N)N)C)O

InChI Key InChIKey=ARBRHWRTXPWZGN-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50598851   

LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCREB-binding protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 300nMAssay Description:Inhibition of CREBBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent