BDBM50597108 CHEMBL5184251::US20230287003, Example 1v

SMILES CN1c2ccc(cc2C3=C(C1=O)OCC([C@@H](N3)C4CC4)(F)F)Nc5ccnc(c5C#N)Cl

InChI Key InChIKey=NDXNRYJTYFEIAB-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50597108   

TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50: 2.63nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50: 12nMAssay Description:Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal Trx/6His/HRV3C-tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using RSEIISTAPSSWVVPG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)