BDBM50594625 AB-928::AB928::Ab-928::Ab928::ETRUMADENANT::Etrumadenant::US20240376081, Compound D1

SMILES Cc1c(cccc1-c1cc(nc(N)n1)-c1cn(Cc2cccc(n2)C(C)(C)O)nn1)C#N

InChI Key InChIKey=BUXIAWLTBSXYSW-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50594625   

TargetAdenosine receptor A2a(Human)
Shanghai Haiyan Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM50594625(Etrumadenant | Ab-928 | Ab928 | AB-928 | AB928 | E...)
Affinity DataIC50: 65nMAssay Description:The screening procedure was as follows:1. adjusting the cell density to 6×105 cells/mL with serum-free medium;2. adding 5 mL of cytosol, 2.5 mL of NE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Shanghai Haiyan Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM50594625(Etrumadenant | Ab-928 | Ab928 | AB-928 | AB928 | E...)
Affinity DataIC50: 75nMAssay Description:The screening procedure was as follows:1. adjusting the cell density to 6×105 cells/mL with serum-free medium;2. adding 5 mL of cytosol, 2.5 mL of NE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Shanghai Haiyan Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM50594625(Etrumadenant | Ab-928 | Ab928 | AB-928 | AB928 | E...)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed