BDBM50594434 CHEMBL5170344

SMILES CN1C=C(c2ccccc2C1=O)c3cccc(c3)N4CCCC4=O

InChI Key InChIKey=IQHRPUHKLPCOKF-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50594434   

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594434(CHEMBL5170344)
Affinity DataKd:  335nMAssay Description:Inhibition of recombinant human BRD4-1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594434(CHEMBL5170344)
Affinity DataKd:  875nMAssay Description:Inhibition of recombinant human BRDT-1 (21 to 137 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594434(CHEMBL5170344)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BRD4 in human MM1.S cells assessed as reduction in c-MYC level after 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)