BDBM50593227 CHEMBL5177023

SMILES Cc1c(cc(C(F)F)c2cn(nc12)C(C(=O)Nc1nccs1)c1ncn2c1CCC21CC1)C#Cc1ccc(CN2CCC(CO)CC2)cc1

InChI Key InChIKey=XGCQKFFIRIFVIZ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50593227   

TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 200nMAssay Description:Inhibition of adenosine A3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of muscarinic M2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of glucocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 545nMAssay Description:Inhibition of wild type EGFR expressed in human NCI-H2073 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 577nMAssay Description:Inhibition of wild type EGFR expressed in human A-431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed