BDBM50589669 DCC-3014::DP-6865::Dcc-3014::US11679110, Compound 1::VIMSELTINIB::Vimseltinib

SMILES Cc1c(ccc(n1)C2=CN=C(N(C2=O)C)NC(C)C)Oc3ccnc(c3)c4cnn(c4)C

InChI Key InChIKey=TVGAHWWPABTBCX-UHFFFAOYSA-N

Data  18 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50589669   

TargetCytochrome P450 3A4(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of 4 mM ATP measured by cell-based spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of BRK (unknown origin) in presence of 4 mM ATP measured by cell-based spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of KIT (unknown origin) in presence of 4 mM ATP measured by cell-based spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1R (unknown origin) in presence of 4 mM ATP measured by cell-based spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A2(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.20nMAssay Description:The activity of CSF1R kinase (CSF1R, SEQ ID NO: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 27nMAssay Description:Inhibition of CSF1R in CSF1-stimulated human THP-1 cells assessed as inhibition of CSF1R phosphorylation measured by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRbeta (unknown origin) (557 to 1106 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 436nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of His-tagged recombinant human FLT3 (564 to 958 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.70E+3nMAssay Description:The activity of FLT3 kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.50E+3nMAssay Description:The activity of unphosphorylated PDGFRα kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 864nMAssay Description:The activity of unphosphorylated c-KIT kinase (c-KIT, SEQ ID NO: 2) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent