BDBM50588695 CHEMBL5181396

SMILES c1cc2c3cc1CCN4C(=O)C=CC(=N4)c5ccc(c(c5)C(F)(F)F)C(=O)NCCCCn6cc(cn6)-c(c3)cn2

InChI Key InChIKey=PQNIGFMNUHDZKX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50588695   

TargetBDNF/NT-3 growth factors receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal His/SUMO tagged wild type human c-Met (1038 to 1346 residues) transfected in Escherichia coli using Tyr06 peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 401nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 437nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 204nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) in microsomes preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) in microsomes preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in microsomes sing testosterone as a substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50588695(CHEMBL5181396)
Affinity DataIC50: 2.77E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed