BDBM50587872 CHEMBL4553089

SMILES Cc1cccc(c1)c2ccnc3n2ncc3C(=O)N

InChI Key InChIKey=HNKGGVGQAVODNJ-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587872   

TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataIC50: 67nMAssay Description:Inhibition of human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataKd:  220nMAssay Description:Binding affinity to human TLR8 expressed in HEK-Blue hTLR8 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)