BDBM50586288 CHEMBL5070753

SMILES c1ccc(cc1)Oc2ccc3c(c2)C(=O)N(N=C3C(=O)O)Cc4ccc(c(c4)Cl)Cl

InChI Key InChIKey=IQKNCBUBONVBNJ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50586288   

LigandPNGBDBM50586288(CHEMBL5070753)
Affinity DataIC50: 24nMAssay Description:Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50586288(CHEMBL5070753)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50586288(CHEMBL5070753)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant human CYP2C9 preincubated for 10 mins followed by NADPH addition and measured at 20 to 50 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50586288(CHEMBL5070753)
Affinity DataIC50: 160nMAssay Description:Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)