BDBM50585593 CHEMBL5076988

SMILES NCc1n[nH]c(=O)c2ccc(cc12)-c1ccccc1

InChI Key InChIKey=PSGBTNLDNVZJQT-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50585593   

TargetProtein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50585593BDBM50585593(CHEMBL5076988)
Affinity DataKd:  1.62E+3nMAssay Description:Binding affinity to MTA-bound human PRMT5 assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50585593BDBM50585593(CHEMBL5076988)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of MTA-bound human PRMT5 co-complexed with MEP50 using biotin labelled histone H4 peptide (1 to 15) as substrate assessed as inhibition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50585593BDBM50585593(CHEMBL5076988)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human PRMT5 co-complexed with MEP50 in absence of MTA using biotin labelled histone H4 peptide (1 to15) as substrate assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed