BDBM50578341 CHEMBL4860378

SMILES Cc1cc(ncc1N)C

InChI Key InChIKey=SHSQTJRJQHPJRQ-UHFFFAOYSA-N

Data  5 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50578341   

TargetE3 ubiquitin-protein ligase UHRF1(Human)
Yokohama City University

Curated by ChEMBL
LigandPNGBDBM50578341(CHEMBL4860378)
Affinity DataKd:  1.93E+4nMAssay Description:Binding affinity to UHRF1 TTD (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Yokohama City University

Curated by ChEMBL
LigandPNGBDBM50578341(CHEMBL4860378)
Affinity DataKd:  3.20E+4nMAssay Description:Binding affinity to UHRF1 Y188A/Y191A double mutant (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Yokohama City University

Curated by ChEMBL
LigandPNGBDBM50578341(CHEMBL4860378)
Affinity DataKd:  2.07E+4nMAssay Description:Binding affinity to UHRF1 TTD variant loop (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Yokohama City University

Curated by ChEMBL
LigandPNGBDBM50578341(CHEMBL4860378)
Affinity DataKd: >1.11E+5nMAssay Description:Binding affinity to UHRF1 M224A mutant (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase UHRF1(Human)
Yokohama City University

Curated by ChEMBL
LigandPNGBDBM50578341(CHEMBL4860378)
Affinity DataKd: >1.83E+5nMAssay Description:Binding affinity to UHRF1 F278A mutant (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)