BDBM50577242 CHEMBL4854762::US20240239774, Example 1

SMILES Cc1c(Cc2ccccc2)c(nn1C)-c1cc(Cl)nc(N)n1

InChI Key InChIKey=VSMTYSWGHKYXOF-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50577242   

TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataIC50: 195nMAssay Description:Inhibition of human soluble adenylyl cyclase assessed as reduction in cAMP levels in the presence of alpha-32p labeled ATP by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataIC50: 92nMAssay Description:Inhibition of human soluble adenylyl cyclase transfected (4-4 clones)in human HEK293 cells assessed as reduction in cAMP levels preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataIC50: 160nMAssay Description:Inhibition of human ADCY10More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataIC50: 159nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataKd:  176nMAssay Description:Binding affinity to human recombinant His-tagged ADCY10 assessed as dissociation constant and measured for 600 sec by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50577242(CHEMBL4854762 | US20240239774, Example 1)
Affinity DataIC50: 159nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent