BDBM50576267 CHEMBL4876194

SMILES CCN1c2c([C@@H]([C@H](NC(=O)c3cccc(c3)C(F)(F)F)C1=O)c1ccc(F)cc1)c(CN)nn2-c1ccccc1

InChI Key InChIKey=QEHZKPQZGREGTJ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576267   

TargetDCN1-like protein 1(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50576267(CHEMBL4876194)
Affinity DataEC50:  300nMAssay Description:Binding affinity to DCN1 in human HCC95 cells assessed as increase in thermal stability measured after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDCN1-like protein 1(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50576267(CHEMBL4876194)
Affinity DataIC50: 110nMAssay Description:Inhibition of DCN1 (unknown origin) dependent cullin neddylation assessed as decrease in NEDD8 transfer from UBE2M to CUL2 using CUL2 as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed