BDBM50573518 CHEMBL4754873

SMILES CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1

InChI Key InChIKey=DMUSMYYDKCXFKR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50573518   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 187nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 367nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 156nMAssay Description:Inhibition of human recombinant CDK12/CyclinK assessed as reduction in substrate phosphorylation using His-c-Myc as substrate preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 283nMAssay Description:Inhibition of human recombinant CDK13/CyclinK assessed as reduction in substrate phosphorylation using His-c-Myc as substrate preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADP(ATP)-biotin probe binding to DNAPK in human Kelly cells incubated for 6 hrs by KiNativ profiling analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of ADP(ATP)-biotin probe binding to RSK2 domain 1 in human Kelly cells incubated for 6 hrs by KiNativ profiling analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573518(CHEMBL4754873)
Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed